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Jack Lawler Selected Research

Thrombospondin 1

5/2024Antiangiogenic Variant of TSP-1 Targets Tumor Cells in Glioblastomas.
5/2024Antiangiogenic Variant of TSP-1 Targets Tumor Cells in Glioblastomas.
1/2020AAV-mediated expression of 3TSR inhibits tumor and metastatic lesion development and extends survival in a murine model of epithelial ovarian carcinoma.
1/2015Thrombospondin-1 in a Murine Model of Colorectal Carcinogenesis.
1/2015Antiangiogenic variant of TSP-1 targets tumor cells in glioblastomas.
10/2014Thrombospondin-1 Modulates Actin Filament Remodeling and Cell Motility in Mouse Mammary Tumor cells in Vitro.
1/2013Thrombospondin-1 Silencing Down-Regulates Integrin Expression Levels in Human Anaplastic Thyroid Cancer Cells with BRAF(V600E): New Insights in the Host Tissue Adaptation and Homeostasis of Tumor Microenvironment.
1/2012Thrombospondin-1 interacts with Trypanosoma cruzi surface calreticulin to enhance cellular infection.
5/2011Thrombospondin 1 inhibits inflammatory lymphangiogenesis by CD36 ligation on monocytes.
4/2011Thrombospondin-1-deficient mice are not protected from bleomycin-induced pulmonary fibrosis.
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Jack Lawler Research Topics

Disease

35Neoplasms (Cancer)
05/2024 - 01/2002
8Inflammation (Inflammations)
12/2018 - 04/2004
7Thyroid Neoplasms (Thyroid Cancer)
12/2018 - 10/2009
5Ovarian Epithelial Carcinoma
01/2022 - 01/2009
5Neoplasm Metastasis (Metastasis)
01/2019 - 03/2009
4Anaplastic Thyroid Carcinoma
01/2023 - 12/2010
4Pancreatic Neoplasms (Pancreatic Cancer)
07/2007 - 03/2005
3Glioblastoma (Glioblastoma Multiforme)
05/2024 - 01/2015
3Ovarian Neoplasms (Ovarian Cancer)
01/2022 - 01/2009
3Thrombosis (Thrombus)
01/2019 - 02/2006
3Papillary Thyroid Cancer
12/2018 - 12/2010
3Vascular System Injuries
01/2017 - 05/2004
3Carcinogenesis
01/2015 - 02/2003
3Carcinoma (Carcinomatosis)
10/2014 - 02/2003
2Hypoxia (Hypoxemia)
09/2021 - 05/2009
2Ascites
01/2019 - 01/2009
2Hyperplasia
01/2017 - 07/2011
2Breast Neoplasms (Breast Cancer)
10/2014 - 03/2009
2Corneal Neovascularization
05/2011 - 04/2004
2Fibrosis (Cirrhosis)
04/2011 - 02/2006
2Hyperoxia
05/2009 - 12/2003
2Necrosis
03/2009 - 08/2005
2Glomerulonephritis
12/2007 - 01/2004
2Myocardial Infarction
08/2006 - 06/2005
1Eye Diseases (Eye Disease)
09/2015
1AIDS-Related Complex (ARC)
07/2014
1Colorectal Neoplasms (Colorectal Cancer)
04/2014
1Infections
01/2012
1Lymphoma (Lymphomas)
06/2011
1Pulmonary Fibrosis (Fibrosing Alveolitis)
04/2011
1Edema (Dropsy)
08/2009
1Hypersensitivity (Allergy)
08/2009
1Contact Dermatitis (Eczema, Contact)
08/2009
1Osteochondrodysplasias (Spondyloepiphyseal Dysplasia)
06/2008
1Pseudoachondroplasia
06/2008

Drug/Important Bio-Agent (IBA)

31Thrombospondin 1IBA
05/2024 - 01/2002
8Transforming Growth Factor beta (TGF-beta)IBA
03/2009 - 01/2002
7Angiogenesis InhibitorsIBA
06/2011 - 03/2004
5Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
11/2022 - 02/2005
5Peptides (Polypeptides)IBA
01/2022 - 01/2005
5Proteins (Proteins, Gene)FDA Link
10/2014 - 04/2004
4ThrombospondinsIBA
07/2011 - 02/2003
4EndostatinsIBA
06/2011 - 03/2004
4Recombinant ProteinsIBA
05/2009 - 03/2005
3IntegrinsIBA
01/2020 - 01/2013
3Tumor Viral Antigens (Large T Antigen)IBA
10/2014 - 02/2006
3type IV collagen alpha3 chain (Goodpasture antigen)IBA
06/2011 - 03/2004
3CollagenIBA
04/2011 - 03/2009
2LigandsIBA
12/2018 - 05/2009
2Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
12/2018 - 07/2012
2AntibodiesIBA
01/2012 - 02/2006
2Angiogenesis Inducing Agents (Angiogenesis Factor)IBA
06/2011 - 02/2005
2Messenger RNA (mRNA)IBA
04/2011 - 06/2005
2PLX 4720IBA
01/2011 - 06/2010
2Phosphotransferases (Kinase)IBA
12/2010 - 04/2004
2Retinaldehyde (Retinal)IBA
05/2009 - 12/2003
2Therapeutic UsesIBA
07/2007 - 03/2005
2von Willebrand FactorIBA
08/2006 - 05/2004
2Transforming Growth Factors (Transforming Growth Factor)IBA
06/2005 - 08/2004
2Glycoproteins (Glycoprotein)IBA
05/2004 - 06/2003
2Cyclophosphamide (Cytoxan)FDA LinkGeneric
03/2004 - 10/2003
2Extracellular Matrix ProteinsIBA
01/2004 - 02/2003
1Tyrosine Kinase InhibitorsIBA
01/2023
1lenvatinibIBA
01/2023
1Immunoglobulin G (IgG)IBA
01/2022
1Cytostatic AgentsIBA
12/2018
1VemurafenibIBA
12/2018
1Sorafenib (BAY 43-9006)FDA Link
12/2018
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
12/2018
1Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
01/2017
1FluvastatinFDA Link
01/2017
1Dextrans (Dextran)FDA Link
01/2015
1MicroRNAs (MicroRNA)IBA
01/2015
1AzoxymethaneIBA
01/2015
1sodium sulfate (sodium bisulfate)FDA LinkGeneric
01/2015
1CalciumIBA
07/2014
1Calcium Release Activated Calcium ChannelsIBA
07/2014
1Arachidonic Acid (Vitamin F)IBA
07/2014
1Calcibiotic Root Canal SealerIBA
04/2014
1Oncogene Proteins (Oncogene Protein)IBA
04/2014
1Histamine (Histamine Dihydrochloride)FDA Link
03/2013
1Serotonin (5 Hydroxytryptamine)IBA
03/2013
1Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA
07/2012
1CalreticulinIBA
01/2012
1Bleomycin (Blenoxane)FDA LinkGeneric
04/2011
1Thyroid Nuclear Factor 1IBA
01/2011
1Differentiation AntigensIBA
01/2011
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
05/2009
1src-Family KinasesIBA
05/2009
1lexatumumabIBA
05/2009
1TNF-Related Apoptosis-Inducing Ligand ReceptorsIBA
05/2009
1NAc- Sar- Gly- Val- (d- allo- Ile)- Thr- Nva- Ile- Arg- ProNEt (ABT 510)IBA
01/2009
1Antineoplastic Agents (Antineoplastics)IBA
01/2009
1Collagen Type IXIBA
06/2008
1Streptozocin (Streptozotocin)FDA Link
12/2007

Therapy/Procedure

13Therapeutics
01/2022 - 06/2004
2Immunotherapy
09/2021 - 01/2019
2Drug Therapy (Chemotherapy)
01/2020 - 02/2015
1Intraperitoneal Injections
01/2020
1Oncolytic Virotherapy
01/2019